1V.B.l.f QUANTUM CHEMICAL INVESTIGATIONS QUANTUM CHEMICAL INVESTIGATIONS OF HEME PROTEINS AND FERREDOXINS
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چکیده
SUMEX is used for the calculation of various one-electron electromagnetic properties of iron containing compounds. The programs were formulated and written by David Steinberg, Michael Chadwick, and David Lo. David Lo was responsible for converting the programs for interactive use on the PDP system. Slight improvements were made by Robert Kirchner, and Sheldon Aronowitz is currently expanding the formulation to include additional spin and oxidation states of the iron atom.
منابع مشابه
Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.
Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. As a member of the [2Fe-2S] cluster-containing ferredoxin family, Fdx1 reduces mitochondrial cytochrome P450 enzymes, which then catalyze; e.g., the conversion of cholesterol to pregnenolone, aldosterone, and cortisol. The high protein sequence similarity between Fdx1 and its...
متن کاملRedox pathways in electron - transfer proteins : Correlations between reactivities , solvent exposure , and unpaired - spin - density distributions ( cytochromes / iron - sulfur proteins / copper proteins )
The relative reactivities toward reduction by free flavin semiquinones of cytochromes (c-type cytochromes, cytochrome b5, c'-type cytochromes) iron-sulfur proteins (high-redox-potential ferredoxins, rubredoxins, low-redoxpotential ferredoxins), and blue copper proteins (plastocyanin, azurins) are shown to correlate with calculations of the solvent exposure of the various prosthetic groups. In t...
متن کاملCharacterization of two soluble ferredoxins as distinct from bound iron-sulfur proteins in the photosynthetic bacterium Rhodospirillum rubrum.
In an earlier investigation (Shanmugam, K. T., Buchanan, B. B., and Arnon, D. I. (1972) Biochim. Biophys. Acta 256, 477-486) the extraction of ferredoxin from Rhodospirillum rubrum cells with the aid of a detergent (Triton X-100) and acetone revealed the existence of two types of ferredoxin (I and II) and led to the conclusion that both are membrane-bound. In the present investigation, ferredox...
متن کاملTailoring an alien ferredoxin to support native-like P450 monooxygenase activity.
A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known.
متن کامل831-838 Insight 3 Lill NS.indd
low-molecular-mass compounds bind to well-defined and evolutionarily conserved sequence motifs either covalently or non-covalently. Organic cofactors include various nucleotides (such as flavin mono nucleotide and flavin adenine dinucleotide), vitamins (biotin, pantothenate and folate) and metal–organic compounds (haem and molybdenum cofactor). Common inorganic cofactors include various metal i...
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تاریخ انتشار 2001